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Postdoc computational chemistry/structural bioinformatics

Postdoc computational chemistry/structural bioinformatics (2 yrs)
Project: Parametrisation of an all-atom force field with non-natural amino acids
The
laboratory has significant expertise in the development of empirical
force fields predicting mutational changes in the free energy of
folding or binding of proteins. The aim of the current project is to
extend the capabilities of the force field towards non-natural amino
acids. This work involves obtaining good estimates of atomic parameters
such as volumes, charges, hydrophobicity and compound properties such
as backbone and sidechain entropy, from datamining and first principle
simulations. You will need a good understanding of the physicochemistry
of organic compounds and their interaction with proteins. The candidate
will have a strong background in computational chemistry or structural
bioinformatics and experience with c++ programming will be considered a
serious plus.


For more information contact Prof. Joost Schymkowitz (joost.schymkowitz@vub.ac.be)

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